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Article

Loss of Function of Canonical Notch Signaling Drives Head and Neck Carcinogenesis

7 Aug 2018

Abstract excerpt

Abstract Purpose: Head and neck squamous cell carcinoma (HNSCC), a common cancer worldwide, is etiologically associated with tobacco use, high alcohol consumption, and high-risk human papillomaviruses (HPV). The Notch signaling pathway, which is involved in cell differentiation decisions with differential downstream targets and effects depending on tissue type and developmental stage, has been implicated in human...

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PMID: 30087145
DOI: 10.1158/1078-0432.ccr-17-3535

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