Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features.

doi:10.1158/1940-6207.CAPR-14-0366

Article

Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features.

Cancer prevention research (Philadelphia, Pa.) - 1 Apr 2015

Rettig Eleni M, Chung Christine H, Bishop Justin A, Howard Jason D, Sharma Rajni, Li Ryan J, Douville Christopher, Karchin Rachel, Izumchenko Evgeny, Sidransky David, Koch Wayne, Califano Joseph, Agrawal Nishant, Fakhry Carole

Abstract excerpt

The Notch pathway is frequently altered in head and neck squamous cell carcinomas (HNSCC); however, the clinical significance of NOTCH1 dysregulation is poorly understood. This study was designed to characterize expression of the transcriptionally active NOTCH1 intracellular domain (NICD1) in HNSCCs and evaluate its association with NOTCH1 mutation status and clinical parameters. IHC for NICD1 was performed on 79...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features.

Abstract excerpt

Topics

Related research