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Impaired Notch Signaling Promotes De novo Squamous Cell Carcinoma Formation

1 Aug 2006

Abstract excerpt

Signaling through Notch receptors in the skin has been implicated in the differentiation, proliferation, and survival of keratinocytes, as well as in the pathogenesis of basal cell carcinoma (BCC). To determine the composite function of Notch receptor-mediated signaling in the skin and overcome potential redundancies between receptors, conditional transgenic mice were generated that express the pan-Notch...

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PMID: 16885339
DOI: 10.1158/0008-5472.can-06-0793

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