Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

QT length during methadone maintenance treatment: gene × dose interaction.

Fundamental & clinical pharmacology - 1 Feb 2019

Zerdazi El-Hadi, Vorspan Florence, Marees Andries T, Naccache François, Lepine Jean-Pierre, Laplanche Jean-Louis, Prince Nathalie, Marie-Claire Cynthia, Bellivier Frank, Mouly Stéphane, Bloch Vanessa

Abstract excerpt

Methadone is known to be a risk factor for sudden death by enlarging ECG QT corrected (QTc) interval. For other medical conditions, QTc lengthening has been described as the result of interactions between pharmacological treatments and genetic factors. Former heroin-dependent subjects under methadone maintenance treatment in remission for at last 3 months were recruited. We studied the association between QTc...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dose-Response Relationship, Drug
Share to Electrocardiography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heroin Dependence

Share to Long QT Syndrome

Share to Methadone

Share to Polymorphism, Single Nucleotide

Share to Potassium Channels, Voltage-Gated

Share to Young Adult

Source

Identifiers

PMID: 30086202
DOI: 10.1111/fcp.12405

Genes

KCNH2
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

QT length during methadone maintenance treatment: gene × dose interaction.PMID 30086202Read ↗

KCNH2 polymorphism and methadone dosage interact to enhance QT duration.Semantic proximity Read ↗

Functional genetic polymorphisms in CYP2C19 gene in relation to cardiac side effects and treatment dose in a methadone maintenance cohort.Semantic proximity Read ↗

Influence of NOS1AP Risk Variants on the Corrected QT (QTc) Interval in the Pharmacotherapy of Schizophrenia.Semantic proximity Read ↗

Precision therapeutic opioid dosing implications from genetic biomarkers and craving score.Semantic proximity Read ↗

Association of the D-amino acid oxidase gene with methadone dose in heroin dependent patients under methadone maintenance treatment.Semantic proximity Read ↗

Opioid maintenance patients with QTc prolongation: congenital long QT syndrome mutation may be a contributing risk factor.Semantic proximity Read ↗

Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction.Semantic proximity Read ↗

A Possible Mechanistic Link Between the CYP2C19 Genotype, the Methadone Metabolite Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidene (EDDP), and Methadone-Induced Corrected QT Interval Prolongation in a Pilot Study.Semantic proximity Read ↗

Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity.Semantic proximity Read ↗

QTc prolongation in short-term treatment of schizophrenia patients: effects of different antipsychotics and genetic factors.Semantic proximity Read ↗

OPRM1 and CYP3A4 association with methadone dose in Iranian patients undergoing methadone maintenance therapy.Semantic proximity Read ↗

Pharmacogenetic study of methadone treatment for heroin addiction: associations between drug-metabolizing gene polymorphisms and treatment efficacy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.