Article
A Possible Mechanistic Link Between the CYP2C19 Genotype, the Methadone Metabolite Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidene (EDDP), and Methadone-Induced Corrected QT Interval Prolongation in a Pilot Study.
Molecular diagnosis & therapy - 1 Apr 2015
Carlquist John F, Moody David E, Knight Stacey, Johnson Eric G, Fang Wenfang B, Huntinghouse John A, Rollo Jeffrey S, Webster Lynn R, Anderson Jeffrey L
Abstract excerpt
BACKGROUND: Methadone use and methadone-associated sudden cardiac death have increased dramatically. Prolongation of the QT interval of the cardiac cycle predisposes to arrhythmia and is common among methadone users. OBJECTIVE: We studied the relationship between pharmacogenetic variables and methadone metabolites and QT prolongation. METHODS: Blood was obtained on days 1, 7, and 21 from consenting individuals...
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