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Article

Functional genetic polymorphisms in CYP2C19 gene in relation to cardiac side effects and treatment dose in a methadone maintenance cohort.

Omics : a journal of integrative biology - 1 Oct 2013

Wang Sheng-Chang, Ho Ing-Kang, Tsou Hsiao-Hui, Liu Sheng-Wen, Hsiao Chin-Fu, Chen Chia-Hui, Tan Happy Kuy-Lok, Lin Linen, Wu Chi-Shin, Su Lien-Wen, Huang Chieh-Liang, Yang Yi-Hong, Liu Ming-Lun, Lin Keh-Ming, Liu Shu Chih, Wu Hsiao-Yu, Kuo Hsiang-Wei, Chen Andrew C H, Chang Yao-Sheng, Liu Yu-Li

Abstract excerpt

Abstract Methadone maintenance therapy is an established treatment for heroin dependence. This study tested the influence of functional genetic polymorphisms in CYP2C19 gene encoding a CYP450 enzyme that contributes to methadone metabolism on treatment dose, plasma concentration, and side effects of methadone. Two single nucleotide polymorphisms (SNPs), rs4986893 (exon 4) and rs4244285 (exon 5), were selected and...

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Share to Aryl Hydrocarbon Hydroxylases
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Identifiers

PMID: 24016178
DOI: 10.1089/omi.2012.0068
PMCID: PMC3783925

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