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Article

QTc prolongation in short-term treatment of schizophrenia patients: effects of different antipsychotics and genetic factors.

European archives of psychiatry and clinical neuroscience - 1 Jun 2018

Spellmann Ilja, Reinhard Matthias A, Veverka Diana, Zill Peter, Obermeier Michael, Dehning Sandra, Schennach Rebecca, Müller Norbert, Möller Hans-Jürgen, Riedel Michael, Musil Richard

Abstract excerpt

Antipsychotics are effective in treating schizophrenia but may lead to a higher cardiovascular risk due to QTc prolongation. Besides drugs, genetic and clinical factors may contribute to QTc prolongation. The aim of this study is to examine the effect of candidate genes known for QTc prolongation and their interaction with common antipsychotics. Thus, 199 patients were genotyped for nine polymorphisms in KCNQ1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29429138
DOI: 10.1007/s00406-018-0880-8

Genes

KCNH2
KCNQ1
NUBPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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