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Article

AND-1 fork protection function prevents fork resection and is essential for proliferation.

Nature communications - 6 Aug 2018

Abe Takuya, Kawasumi Ryotaro, Giannattasio Michele, Dusi Sabrina, Yoshimoto Yui, Miyata Keiji, Umemura Koyuki, Hirota Kouji, Branzei Dana

Abstract excerpt

AND-1/Ctf4 bridges the CMG helicase and DNA polymerase alpha, facilitating replication. Using an inducible degron system in avian cells, we find that AND-1 depletion is incompatible with proliferation, owing to cells accumulating in G2 with activated DNA damage checkpoint. Replication without AND-1 causes fork speed slow-down and accumulation of long single-stranded DNA (ssDNA) gaps at the replication fork...

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Topics

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Share to DNA Breaks, Double-Stranded
Share to DNA Polymerase I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA, Single-Stranded

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Source

Open in PubMed Open full text

Identifiers

PMID: 30082684
DOI: 10.1038/s41467-018-05586-7
PMCID: PMC6079002

Genes

MRE11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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