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Article

Oncohistone Mutations in Diffuse Intrinsic Pontine Glioma.

Trends in cancer - 1 Dec 2019

Zhang Xu, Zhang Zhiguo

Abstract excerpt

Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric tumor with no currently available treatment options. More than 60-70% DIPG tumors harbor heterozygous mutations at genes encoding histone H3 proteins that replace lysine 27 with methionine (K27M). In this review, we discuss how K27M mutation reprograms the cancer epigenome to lead to tumorigenesis, and highlight potential drug targets and therapeutic...

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PMID: 31813457
DOI: 10.1016/j.trecan.2019.10.009
PMCID: PMC6986369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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