Article
The dark side of histones: genomic organization and role of oncohistones in cancer.
Clinical epigenetics - 7 Apr 2021
Amatori Stefano, Tavolaro Simona, Gambardella Stefano, Fanelli Mirco
Abstract excerpt
BACKGROUND: The oncogenic role of histone mutations is one of the most relevant discovery in cancer epigenetics. Recurrent mutations targeting histone genes have been described in pediatric brain tumors, chondroblastoma, giant cell tumor of bone and other tumor types. The demonstration that mutant histones can be oncogenic and drive the tumorigenesis in pediatric tumors, led to the coining of the term...
Topics
- Carcinogenesis
- Epigenesis, Genetic
- Genome
- Histones
- Humans
- Mutation
- Neoplasms