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Article

Biochemical and kinetic properties of the complex Roco G-protein cycle.

Biological chemistry - 27 Nov 2018

Wauters Lina, Terheyden Susanne, Gilsbach Bernd K, Leemans Margaux, Athanasopoulos Panagiotis S, Guaitoli Giambattista, Wittinghofer Alfred, Gloeckner Christian Johannes, Versées Wim, Kortholt Arjan

Abstract excerpt

Roco proteins have come into focus after mutations in the gene coding for the human Roco protein Leucine-rich repeat kinase 2 (LRRK2) were discovered to be one of the most common genetic causes of late onset Parkinson's disease. Roco proteins are characterized by a Roc domain responsible for GTP binding and hydrolysis, followed by a COR dimerization device. The regulation and function of this RocCOR domain tandem...

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PMID: 30067506
DOI: 10.1515/hsz-2018-0227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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