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The function of ROCO proteins in health and disease

22 Jan 2009

Abstract excerpt

The ROCO family of multidomain proteins extends across the eukaryotes, and has been implicated in numerous cellular processes. Following the description of mutations causing PD (Parkinson's disease) in a human representative of the ROCO family, LRRK2 (leucine-rich repeat kinase 2), a great deal of research has been carried out into these proteins. This review examines the published data regarding the roles the...

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PMID: 19152505
DOI: 10.1042/bc20080053

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