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Article

Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8 <sup>+</sup> T cells in autoimmune diabetes

18 Jun 2003

Abstract excerpt

Type 1 diabetes is an autoimmune disease in which autoreactive T cells attack and destroy the insulin-producing pancreatic beta cells. CD8+ T cells are essential for this beta cell destruction, yet their specific antigenic targets are largely unknown. Here, we reveal that the autoantigen targeted by a prevalent population of pathogenic CD8+ T cells in nonobese diabetic mice is islet-specific glucose-6-phosphatase...

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Identifiers

PMID: 12815107
DOI: 10.1073/pnas.0932778100

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