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Article

Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2011

Chen Yi-Guang, Scheuplein Felix, Driver John P, Hewes Amanda A, Reifsnyder Peter C, Leiter Edward H, Serreze David V

Abstract excerpt

Although P2rx7 has been proposed as a type 1 diabetes (T1D) susceptibility gene in NOD mice, its potential pathogenic role has not been directly determined. To test this possibility, we generated a new NOD stock deficient in P2X(7) receptors. T1D development was not altered by P2X(7) ablation. Previous studies found CD38 knockout (KO) NOD mice developed accelerated T1D partly because of a loss of CD4(+) invariant...

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Identifiers

PMID: 21357538
DOI: 10.4049/jimmunol.1003733
PMCID: PMC3094905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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