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Article

P2X7 Variants in Pathophysiology

18 Jun 2024

Abstract excerpt

P2X7 receptor activation by extracellular adenosine triphosphate (eATP) modulates different intracellular pathways, including pro-inflammatory and tumor-promoting cascades. ATP is released by cells and necrotic tissues during stressful conditions and accumulates mainly in the inflammatory and tumoral microenvironments. As a consequence, both the P2X7 blockade and agonism have been proposed as therapeutic...

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PMID: 38928378
DOI: 10.3390/ijms25126673

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