Article
In vivo targeted single-nucleotide editing in zebrafish.
Scientific reports - 30 Jul 2018
Tanaka Shingo, Yoshioka Shin, Nishida Keiji, Hosokawa Hiroshi, Kakizuka Akira, Maegawa Shingo
Abstract excerpt
To date, several genome editing technologies have been developed and are widely utilized in many fields of biology. Most of these technologies, if not all, use nucleases to create DNA double-strand breaks (DSBs), raising the potential risk of cell death and/or oncogenic transformation. The risks hinder their therapeutic applications in humans. Here, we show that in vivo targeted single-nucleotide editing in...
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