Article

TadA-Derived Cytosine Base Editor for Precise Genome Editing in Zebrafish

2025-01-28

Abstract excerpt

CRISPR base editors are crucial for precise genome manipulation. Existing APOBEC-based cytosine base editors (CBEs), while powerful, exhibit indels and sequence context limitations, where TC-context preferences restrict effective editing of CC and GC motifs. To address these challenges, we evaluated various tRNA adenine deaminase (TadA)-derived CBEs, ultimately engineering zTadCBE that demonstrates high editing ef...

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Literature Corpus work: 240bbfa6-7b41-5339-94ca-76a4d5744839
DOI: 10.1101/2025.01.28.635338

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