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Article

Precise A•T to G•C base editing in the zebrafish genome

20 Nov 2018

Abstract excerpt

BACKGROUND: Base editors are a class of genome editing tools with the ability to efficiently induce point mutations in genomic DNA, without inducing double-strand breaks or relying on homology-direct repair as in other such technologies. Recently, adenine base editors (ABEs) have been developed to mediate the conversion of A•T to G•C in genomic DNA of human cells, mice, and plants. Here, we investigated the...

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PMID: 30458760
DOI: 10.1186/s12915-018-0609-1

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