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Sequence Context‐Agnostic TadA‐Derived Cytosine Base Editors for Genome‐Wide Editing in Zebrafish

17 Feb 2025

Abstract excerpt

Abstract Single‐nucleotide variants (SNVs) represent a significant form of genetic variation linked to various diseases. CRISPR‐mediated base editing has emerged as a powerful method for modeling diseases caused by SNVs, particularly in zebrafish, which serve as an excellent platform for investigating disease mechanisms and conducting drug screenings. However, existing cytosine base editors (CBEs) for zebrafish...

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PMID: 39960330
DOI: 10.1002/advs.202411478

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