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Article

Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2014

Seijkens Tom, Hoeksema Marten A, Beckers Linda, Smeets Esther, Meiler Svenja, Levels Johannes, Tjwa Marc, de Winther Menno P J, Lutgens Esther

Abstract excerpt

Modulation of hematopoietic stem and progenitor cells (HSPCs) determines immune cell function. In this study, we investigated how hypercholesterolemia affects HSPC biology and atherosclerosis. Hypercholesterolemia induced loss of HSPC quiescence, characterized by increased proliferation and expression of cyclin B1, C1, and D1, and a decreased expression of Rb, resulting in a 3.6- fold increase in the number of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24481967
DOI: 10.1096/fj.13-243105

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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