Article
The effect of dietary sphingolipids on plasma sphingomyelin metabolism and atherosclerosis.
Biochimica et biophysica acta - 15 Jul 2005
Li Zhiqiang, Basterr Maria J, Hailemariam Tiruneh K, Hojjati Mohammad Reza, Lu Shendi, Liu Jin, Liu Ruijie, Zhou Hongwen, Jiang Xian-Cheng
Abstract excerpt
Sphingomyelin (SM) plays a very important role in cell membrane formation and plasma lipoprotein metabolism. All these functions may have an impact on atherosclerotic development. To investigate the relationship between SM metabolism and atherosclerosis, we utilized a sphingolipid-rich diet to feed LDL receptor gene knockout (LDLr KO) mice and studied lipid metabolism and atherosclerosis in the mice. After 3...
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