Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Platelet protease activated receptor 4 (PAR 4) receptor genotype is associated with an increased risk of preterm birth.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2022

Boelig Rupsa C, Cahanap Tara J, Ma Lin, Zhan Tingting, Berghella Vincenzo, Chan Joanna S Y, Kraft Walter K, Mckenzie Steven E

Abstract excerpt

BACKGROUND: Platelet protease activated receptor-4 (PAR4) Thr120 is a common genetic variant associated with increased platelet activity. Increased platelet activity is implicated in the pathogenesis of preeclampsia and preterm birth. OBJECTIVE: Compare the rate of preeclampsia and preterm birth in pregnant individuals homozygous for PAR4 Thr120 variant vs not. STUDY DESIGN: This is a prospective cohort study of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension, Pregnancy-Induced

Share to Infant, Newborn

Share to Placenta

Share to Pre-Eclampsia

Share to Pregnancy

Share to Premature Birth

Source

Identifiers

PMID: 35815338
DOI: 10.1111/jth.15814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Platelet protease activated receptor 4 (PAR 4) receptor genotype is associated with an increased risk of preterm birth.PMID 35815338Read ↗

Maternal genotype and severe preeclampsia: a HuGE review.Semantic proximity Read ↗

Protease activated receptor-4: ready to be part of the antithrombosis spectrum.Semantic proximity Read ↗

Protease-activated receptor-4 (PAR4) variant influences on platelet reactivity induced by PAR4-activating peptide through altered Ca2+ mobilization and ERK phosphorylation in healthy Japanese subjects.Semantic proximity Read ↗

The relationship between Toll-like receptor-4 genes and preeclampsia outcomes.Semantic proximity Read ↗

The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y12 inhibition.Semantic proximity Read ↗

Association study of protease activated receptor 1 gene polymorphisms and adverse pregnancy outcomes: results of a pilot study in Israel.Semantic proximity Read ↗

The effect of AT1R-1166A/C and AT2R-1675A/G polymorphisms on susceptibility to preeclampsia: A systematic review and meta-analysis.Semantic proximity Read ↗

Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP.Semantic proximity Read ↗

Determination of PAR4 numbers on the surface of human platelets: no effect of the single nucleotide polymorphism rs773902.Semantic proximity Read ↗

Genetic thrombophilia variants and risk for preeclampsia among American Indians.Semantic proximity Read ↗

Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury.Semantic proximity Read ↗

Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.