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Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses

2023-11-08

Abstract excerpt

Antibodies are central to immune defenses. Despite advances in understanding the mechanisms of antibody generation, a comprehensive model of how intrinsic and external factors shape human humoral responses to viruses is lacking. Here, we apply PhIP-Seq to investigate the effects of demographic and genetic factors on antibody reactivity to more than 97,000 viral peptides in 1,212 healthy adults. We demonstrate that...

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Identifiers and source

Literature Corpus work
90f7b911-026a-53cf-a89a-bf2416a0b7f6
DOI
10.1101/2023.11.07.23298153
Open publication

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Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against virusesDOI 10.1101/2023.11.07.23298153
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