Article

Genetic, environmental and intrinsic determinants of the human antibody epitope repertoire

2021-12-08

Abstract excerpt

Phage-displayed immunoprecipitation sequencing (PhIP-Seq) has successfully enabled high-throughput profiling of human antibody profiles. However, a comprehensive overview of environmental and genetic determinants shaping human adaptive immunity is currently lacking. In this study, we aimed to investigate the effects of genetic, environmental and intrinsic factors on the variation in human antibody repertoires. We...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bbc0172b-539e-57b8-b149-54f4c02de56d
DOI: 10.1101/2021.12.07.471553

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic, environmental and intrinsic determinants of the human antibody epitope repertoireDOI 10.1101/2021.12.07.471553Read

Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses.Semantic proximity Read

Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against virusesSemantic proximity Read

Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoireSemantic proximity Read

Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire.Semantic proximity Read

Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoireSemantic proximity Read

The Individual and Population Genetics of Antibody Immunity.Semantic proximity Read

Antibody signatures against viruses and microbiome reflect past and chronic exposures and associate with aging and inflammationSemantic proximity Read

Antibody sequence determinants of viral antigen specificitySemantic proximity Read

Genetic factors and age are the strongest predictors of humoral immune responses to common pathogens and vaccinesSemantic proximity Read

The landscape of host genetic factors involved in immune response to common viral infections.Semantic proximity Read

Autoreactomes in Healthy Individuals Vary According to HLA Class II GenotypeSemantic proximity Read

Human genetic variation shapes the antibody repertoire across B cell developmentSemantic proximity Read