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Article

Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses.

American journal of human genetics - 5 Nov 2015

Hammer Christian, Begemann Martin, McLaren Paul J, Bartha István, Michel Angelika, Klose Beate, Schmitt Corinna, Waterboer Tim, Pawlita Michael, Schulz Thomas F, Ehrenreich Hannelore, Fellay Jacques

Abstract excerpt

The magnitude of the human antibody response to viral antigens is highly variable. To explore the human genetic contribution to this variability, we performed genome-wide association studies of the immunoglobulin G response to 14 pathogenic viruses in 2,363 immunocompetent adults. Significant associations were observed in the major histocompatibility complex region on chromosome 6 for influenza A virus,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26456283
DOI: 10.1016/j.ajhg.2015.09.008
PMCID: PMC4667104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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