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Article

The landscape of host genetic factors involved in immune response to common viral infections.

Genome medicine - 27 Oct 2020

Kachuri Linda, Francis Stephen S, Morrison Maike L, Wendt George A, Bossé Yohan, Cavazos Taylor B, Rashkin Sara R, Ziv Elad, Witte John S

Abstract excerpt

BACKGROUND: Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the genetic mechanisms of immune response to viral infection provides insight into disease etiology and therapeutic opportunities. METHODS: We conducted a comprehensive study including genome-wide and transcriptome-wide association analyses to identify genetic loci associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33109261
DOI: 10.1186/s13073-020-00790-x
PMCID: PMC7590248

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