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Article

Deletion of cadherin-17 enhances intestinal permeability and susceptibility to intestinal tumour formation.

The Journal of pathology - 1 Nov 2018

Chang Ya-Yun, Yu Linda Chia-Hui, Yu I-Shing, Jhuang Yu-Lin, Huang Wei-Ju, Yang Ching-Yao, Jeng Yung-Ming

Abstract excerpt

Cadherin-17 is an adhesion molecule expressed specifically in intestinal epithelial cells. It is frequently underexpressed in human colorectal cancer. The physiological function of cadherin-17 and its role in tumourigenesis have not yet been determined. We used the transcription activator-like effector nuclease technique to generate a Cdh17 knockout (KO) mouse model. Intestinal tissues were analysed with...

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PMID: 30047135
DOI: 10.1002/path.5138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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