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Article

Cutting edge: regulation of intestinal inflammation and barrier function by IL-17C.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2012

Reynolds Joseph M, Martinez Gustavo J, Nallaparaju Kalyan C, Chang Seon Hee, Wang Yi-Hong, Dong Chen

Abstract excerpt

In the IL-17 family of cytokines, much is known about the sources and functions of IL-17, IL-17F, and IL-25 in the host defense against infection and in inflammatory diseases; however, the physiological function of IL-17C remains poorly understood. Using mice deficient in IL-17C, we demonstrate that this cytokine is crucial for the regulation of an acute experimental colitis elicited by dextran sulfate sodium. In...

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Identifiers

PMID: 23024280
DOI: 10.4049/jimmunol.1103014
PMCID: PMC3478486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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