Article
Functional involvement of CD44 variant 7 in gut immune response.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2000
Wittig Bianca M, Stallmach Andreas, Zeitz Martin, Günthert Ursula
Abstract excerpt
A major problem in inflammatory bowel disease (IBD) is the accumulation of highly activated T-helper cells that are refractory to apoptosis induction. Hence, persistent inflammatory lesions are prevalent and are the basis of chronic disease. In IBD upregulation of costimulatory molecules on lamina propria lymphocytes has been described leading to apoptosis resistance. CD44 is a cell adhesion molecule and a...
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