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Article

Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America - 23 Mar 2010

Chae Wook-Jin, Gibson Thomas F, Zelterman Daniel, Hao Liming, Henegariu Octavian, Bothwell Alfred L M

Abstract excerpt

The intrinsic role of endogenous IL-17A in spontaneous intestinal tumorigenesis has not been addressed previously to our knowledge. Ablation of IL-17A significantly reduced tumor development in mice bearing a heterozygote mutation in the adenomatous polyposis coli (APC) gene (Apc(Min/+) mice). Th...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20212110
DOI: 10.1073/pnas.0912675107
PMCID: PMC2851824

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20212110-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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