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Article

Induction and down-regulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis.

Gastroenterology - 1 Oct 2009

Du Yu-Chen, Oshima Hiroko, Oguma Keisuke, Kitamura Takanori, Itadani Hiraku, Fujimura Takashi, Piao Ying-Shi, Yoshimoto Tanihiro, Minamoto Toshinari, Kotani Hidehito, Taketo Makoto M, Oshima Masanobu

Abstract excerpt

BACKGROUND & AIMS: The activation of Wnt/beta-catenin signaling causes the development of gastric and colon cancers. Sox17 represses Wnt/beta-catenin signaling and is down-regulated in colon cancer. This study was designed to elucidate the role of Sox17 during the course of gastrointestinal tumorigenesis. METHODS: Sox17 expression was examined in gastrointestinal tumors of mouse models and humans. The roles of...

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Identifiers

PMID: 19549530
DOI: 10.1053/j.gastro.2009.06.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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