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Article

β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers.

Scientific reports - 5 Dec 2019

Kim Won Kyu, Kwon Yujin, Jang Mi, Park Minhee, Kim Jiyoon, Cho Suyeon, Jang Dong Geon, Lee Wook-Bin, Jung Sang Hoon, Choi Hye Jin, Min Byung Soh, Il Kim Tae, Hong Sung Pil, Paik Young-Ki, Kim Hoguen

Abstract excerpt

WNT signaling activation in colorectal cancers (CRCs) occurs through APC inactivation or β-catenin mutations. Both processes promote β-catenin nuclear accumulation, which up-regulates epithelial-to-mesenchymal transition (EMT). We investigated β-catenin localization, transcriptome, and phenotypic differences of HCT116 cells containing a wild-type (HCT116-WT) or mutant β-catenin allele (HCT116-MT), or parental...

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Identifiers

PMID: 31804558
DOI: 10.1038/s41598-019-54890-9
PMCID: PMC6895046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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