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Article

Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks.

Nature communications - 25 Jul 2018

Pelikan Richard C, Kelly Jennifer A, Fu Yao, Lareau Caleb A, Tessneer Kandice L, Wiley Graham B, Wiley Mandi M, Glenn Stuart B, Harley John B, Guthridge Joel M, James Judith A, Aryee Martin J, Montgomery Courtney, Gaffney Patrick M

Abstract excerpt

Genetic variants can confer risk to complex genetic diseases by modulating gene expression through changes to the epigenome. To assess the degree to which genetic variants influence epigenome activity, we integrate epigenetic and genotypic data from lupus patient lymphoblastoid cell lines to identify variants that induce allelic imbalance in the magnitude of histone post-translational modifications, referred to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30046115
DOI: 10.1038/s41467-018-05328-9
PMCID: PMC6060153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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