Article
The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis.
PloS one - 1 Jan 2018
Fernández-Rhodes Lindsay, Malinowski Jennifer R, Wang Yujie, Tao Ran, Pankratz Nathan, Jeff Janina M, Yoneyama Sachiko, Carty Cara L, Setiawan V Wendy, Le Marchand Loic, Haiman Christopher, Corbett Steven, Demerath Ellen, Heiss Gerardo, Gross Myron, Buzkova Petra, Crawford Dana C, Hunt Steven C, Rao D C, Schwander Karen, Chakravarti Aravinda, Gottesman Omri, Abul-Husn Noura S, Bottinger Erwin P, Loos Ruth J F, Raffel Leslie J, Yao Jie, Guo Xiuqing, Bielinski Suzette J, Rotter Jerome I, Vaidya Dhananjay, Chen Yii-Der Ida, Castañeda Sheila F, Daviglus Martha, Kaplan Robert, Talavera Gregory A, Ryckman Kelli K, Peters Ulrike, Ambite Jose Luis, Buyske Steven, Hindorff Lucia, Kooperberg Charles, Matise Tara, Franceschini Nora, North Kari E
Abstract excerpt
Current knowledge of the genetic architecture of key reproductive events across the female life course is largely based on association studies of European descent women. The relevance of known loci for age at menarche (AAM) and age at natural menopause (ANM) in diverse populations remains unclear. We investigated 32 AAM and 14 ANM previously-identified loci and sought to identify novel loci in a trans-ethnic...
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