Article
Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche.
Human reproduction (Oxford, England) - 18 Jun 2021
Sarnowski C, Cousminer D L, Franceschini N, Raffield L M, Jia G, Fernández-Rhodes L, Grant S F A, Hakonarson H, Lange L A, Long J, Sofer T, Tao R, Wallace R B, Wong Q, Zirpoli G, Boerwinkle E, Bradfield J P, Correa A, Kooperberg C L, North K E, Palmer J R, Zemel B S, Zheng W, Murabito J M, Lunetta K L
Abstract excerpt
STUDY QUESTION: Does the expansion of genome-wide association studies (GWAS) to a broader range of ancestries improve the ability to identify and generalise variants associated with age at menarche (AAM) in European populations to a wider range of world populations? SUMMARY ANSWER: By including women with diverse and predominantly non-European ancestry in a large-scale meta-analysis of AAM with half of the women...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.