Article
Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study.
PloS one - 1 Jan 2013
Spencer Kylee L, Malinowski Jennifer, Carty Cara L, Franceschini Nora, Fernández-Rhodes Lindsay, Young Alicia, Cheng Iona, Ritchie Marylyn D, Haiman Christopher A, Wilkens Lynne, Chunyuanwu, Matise Tara C, Carlson Christopher S, Brennan Kathleen, Park Amy, Rajkovic Aleksandar, Hindorff Lucia A, Buyske Steven, Crawford Dana C
Abstract excerpt
Age at menarche (AM) and age at natural menopause (ANM) define the boundaries of the reproductive lifespan in women. Their timing is associated with various diseases, including cancer and cardiovascular disease. Genome-wide association studies have identified several genetic variants associated with either AM or ANM in populations of largely European or Asian descent women. The extent to which these associations...
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