Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of loci associated with women's reproductive traits and exploration of a shared genetic basis with obesity.

Human genomics - 20 May 2025

Kwon Seong-Ah, Cho Yoon Shin

Abstract excerpt

BACKGROUND: The timing of menarche and menopause significantly affects women's health, with influences on cancer, cardiovascular disease, obesity, type 2 diabetes, and psychosocial problems. In addition, observational studies have reported that ages at menarche (AAM) and natural menopause (ANM) are correlated with obesity. To understand the genetic bases of these reproductive traits, we conducted a genome-wide...

Topics

Humans
Female
Obesity
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Menarche
Menopause
Adult
Genetic Predisposition to Disease
Middle Aged
Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reproduction

Body Mass Index

Republic of Korea

Source

Open in PubMed Open full text

Identifiers

PMID: 40394640
DOI: 10.1186/s40246-025-00773-2
PMCID: PMC12093848

Genes

JHY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of loci associated with women's reproductive traits and exploration of a shared genetic basis with obesity.PMID 40394640Read ↗

Genetic Perspective on the Relationship between Female Reproductive Traits, Exercise, and Bone Health Outcomes: Evidence from a National Database.Semantic proximity Read ↗

Using genetic instruments to estimate the causal effect of hormonal reproductive factors on osteoarthritis.Semantic proximity Read ↗

Joint Genome-Wide Association Analyses Identified 49 Novel Loci For Age at Natural Menopause.Semantic proximity Read ↗

Menarche-a journey into womanhood: age at menarche and health-related outcomes in East Asians.Semantic proximity Read ↗

Joint Genome-Wide Association Study Identifies Twenty-One Novel Loci for Age at Menarche and Highlights Its Causal Association with Other Complex DiseasesSemantic proximity Read ↗

The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis.Semantic proximity Read ↗

The genetic architecture of age at menarche and its causal effects on other traits.Semantic proximity Read ↗

Genetic and environmental correlations between obesity phenotypes and age at menarche.Semantic proximity Read ↗

Causal relationship between the timing of menarche and young adult body mass index with consideration to a trend of consistently decreasing age at menarche.Semantic proximity Read ↗

Shared genetic factors for age at natural menopause in Iranian and European women.Semantic proximity Read ↗

The future for genetic studies in reproduction.Semantic proximity Read ↗

Evaluating GWAS-identified SNPs for age at natural menopause among chinese women.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.