Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Positive selection on schizophrenia-associated ST8SIA2 gene in post-glacial Asia.

PloS one - 1 Jan 2018

Fujito Naoko T, Satta Yoko, Hane Masaya, Matsui Atsushi, Yashima Kenta, Kitajima Ken, Sato Chihiro, Takahata Naoyuki, Hayakawa Toshiyuki

Abstract excerpt

A number of loci are associated with highly heritable schizophrenia and the prevalence of this mental illness has had considerable negative fitness effects on human populations. Here we focused on one particular schizophrenia-associated gene that encodes a sialyltransferase (ST8SIA2) and is expressed preferentially in the brain with the level being largely determined by three SNPs in the promoter region. It is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asia
Share to Geography, Medical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to History, Ancient

Share to Homozygote

Share to Promoter Regions, Genetic

Share to Schizophrenia

Share to Selection, Genetic

Share to Sialyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 30044798
DOI: 10.1371/journal.pone.0200278
PMCID: PMC6059407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Positive selection on schizophrenia-associated ST8SIA2 gene in post-glacial Asia.PMID 30044798Read ↗

Lower promoter activity of the ST8SIA2 gene has been favored in evolving human collective brains.Semantic proximity Read ↗

Lower promoter activity of the <i>ST8SIA2</i> gene has been favored in evolving human collective brainsSemantic proximity Read ↗

Interrogating the Evolutionary Paradox of Schizophrenia: A Novel Framework and Evidence Supporting Recent Negative Selection of Schizophrenia Risk AllelesSemantic proximity Read ↗

Recent Positive Selection Drives the Expansion of a Schizophrenia Risk Nonsynonymous Variant at SLC39A8 in Europeans.Semantic proximity Read ↗

Genetic Markers of Human Evolution Are Enriched in Schizophrenia.Semantic proximity Read ↗

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.Semantic proximity Read ↗

Genetic Variations in Evolutionary Accelerated Regions Disrupt Cognition in SchizophreniaSemantic proximity Read ↗

Genetic variations in evolutionary accelerated regions disrupt cognition in schizophrenia.Semantic proximity Read ↗

Revisiting Schizophrenia from an Evolutionary Perspective: An Association Study of Recent Evolutionary Markers and Schizophrenia.Semantic proximity Read ↗

Positive association between SIAT8B and schizophrenia in the Chinese Han population.Semantic proximity Read ↗

Genetic analysis of common variants in the HDAC2 gene with schizophrenia susceptibility in Han Chinese.Semantic proximity Read ↗

Identification of sialyltransferase 8B as a generalized susceptibility gene for psychotic and mood disorders on chromosome 15q25-26.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.