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Article

Lower promoter activity of the ST8SIA2 gene has been favored in evolving human collective brains.

PloS one - 1 Jan 2021

Hayakawa Toshiyuki, Terahara Masahiro, Fujito Naoko T, Matsunaga Takumi, Teshima Kosuke M, Hane Masaya, Kitajima Ken, Sato Chihiro, Takahata Naoyuki, Satta Yoko

Abstract excerpt

ST8SIA2 is an important molecule regulating expression of the phenotype involved in schizophrenia. Lowered promoter activity of the ST8SIA2 gene is considered to be protective against schizophrenia by conferring tolerance to psychosocial stress. Here, we examined the promoter-type composition of anatomically modern humans (AMHs) and archaic humans (AHs; Neanderthals and Denisovans), and compared the promoter...

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Identifiers

PMID: 34914745
DOI: 10.1371/journal.pone.0259897
PMCID: PMC8675693

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