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Article

Recent Positive Selection Drives the Expansion of a Schizophrenia Risk Nonsynonymous Variant at SLC39A8 in Europeans.

Schizophrenia bulletin - 1 Jan 2016

Li Ming, Wu Dong-Dong, Yao Yong-Gang, Huo Yong-Xia, Liu Jie-Wei, Su Bing, Chasman Daniel I, Chu Audrey Y, Huang Tao, Qi Lu, Zheng Yan, Luo Xiong-Jian

Abstract excerpt

Natural selection has played important roles in optimizing complex human adaptations. However, schizophrenia poses an evolutionary paradox during human evolution, as the illness has strongly negative effects on fitness, but persists with a prevalence of ~0.5% across global populations. Recent studies have identified numerous risk variations in diverse populations, which might be able to explain the stable and...

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Identifiers

PMID: 26006263
DOI: 10.1093/schbul/sbv070
PMCID: PMC4681542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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