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Article

Genetic Markers of Human Evolution Are Enriched in Schizophrenia.

Biological psychiatry - 15 Aug 2016

Srinivasan Saurabh, Bettella Francesco, Mattingsdal Morten, Wang Yunpeng, Witoelar Aree, Schork Andrew J, Thompson Wesley K, Zuber Verena, Winsvold Bendik S, Zwart John-Anker, Collier David A, Desikan Rahul S, Melle Ingrid, Werge Thomas, Dale Anders M, Djurovic Srdjan, Andreassen Ole A

Abstract excerpt

BACKGROUND: Why schizophrenia has accompanied humans throughout our history despite its negative effect on fitness remains an evolutionary enigma. It is proposed that schizophrenia is a by-product of the complex evolution of the human brain and a compromise for humans' language, creative thinking, and cognitive abilities. METHODS: We analyzed recent large genome-wide association studies of schizophrenia and a...

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Identifiers

PMID: 26681495
DOI: 10.1016/j.biopsych.2015.10.009
PMCID: PMC5397584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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