Article
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.
Nature genetics - 1 Mar 2018
Pardiñas Antonio F, Holmans Peter, Pocklington Andrew J, Escott-Price Valentina, Ripke Stephan, Carrera Noa, Legge Sophie E, Bishop Sophie, Cameron Darren, Hamshere Marian L, Han Jun, Hubbard Leon, Lynham Amy, Mantripragada Kiran, Rees Elliott, MacCabe James H, McCarroll Steven A, Baune Bernhard T, Breen Gerome, Byrne Enda M, Dannlowski Udo, Eley Thalia C, Hayward Caroline, Martin Nicholas G, McIntosh Andrew M, Plomin Robert, Porteous David J, Wray Naomi R, Caballero Armando, Geschwind Daniel H, Huckins Laura M, Ruderfer Douglas M, Santiago Enrique, Sklar Pamela, Stahl Eli A, Won Hyejung, Agerbo Esben, Als Thomas D, Andreassen Ole A, Bækvad-Hansen Marie, Mortensen Preben Bo, Pedersen Carsten Bøcker, Børglum Anders D, Bybjerg-Grauholm Jonas, Djurovic Srdjan, Durmishi Naser, Pedersen Marianne Giørtz, Golimbet Vera, Grove Jakob, Hougaard David M, Mattheisen Manuel, Molden Espen, Mors Ole, Nordentoft Merete, Pejovic-Milovancevic Milica, Sigurdsson Engilbert, Silagadze Teimuraz, Hansen Christine Søholm, Stefansson Kari, Stefansson Hreinn, Steinberg Stacy, Tosato Sarah, Werge Thomas, Collier David A, Rujescu Dan, Kirov George, Owen Michael J, O'Donovan Michael C, Walters James T R
Abstract excerpt
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life and decreased life expectancy. Lack of progress in improving treatment outcomes has been attributed to limited knowledge of the underlying biology, although large-scale genomic studies have begun to provide insights. We report a new genome-wide association study of schizophrenia (11,260 cases and 24,542 controls), and...
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