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Intracellular and extracellular TGF-β signaling in cancer: some recent topics

24 Jul 2018

Abstract excerpt

Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively studied and well-characterized in many cancers, especially at early stages, accumulating evidence has...

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PMID: 30043220
DOI: 10.1007/s11684-018-0646-8

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