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Article

Brain region- and sex-specific alterations in DAMGO-stimulated [(35) S]GTPγS binding in mice with Oprm1 A112G.

Addiction biology - 1 May 2014

Wang Yu-Jun, Huang Peng, Blendy Julie A, Liu-Chen Lee-Yuan

Abstract excerpt

The A118G single nucleotide polymorphism (SNP) of the human μ-opioid receptor (MOPR) gene (OPRM1) was associated with heightened dopamine release by alcohol intake, better treatment outcome for nicotine and alcohol addiction, and reduced analgesic responses to morphine. A mouse model that possesses the equivalent substitution (A112G) in the mouse MOPR gene (OPRM1) was generated to delineate the mechanisms of the...

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Source

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Identifiers

PMID: 22862850
DOI: 10.1111/j.1369-1600.2012.00484.x
PMCID: PMC3864546

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Brain region- and sex-specific alterations in DAMGO-stimulated [(35) S]GTPγS binding in mice with Oprm1 A112G.PMID 22862850Read ↗

Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G.Semantic proximity Read ↗

Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior.Semantic proximity Read ↗

Oprm1 A112G, a single nucleotide polymorphism, alters expression of stress-responsive genes in multiple brain regions in male and female mice.Semantic proximity Read ↗

Genetic variation in the behavioral effects of buprenorphine in female mice derived from a murine model of the OPRM1 A118G polymorphism.Semantic proximity Read ↗

OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.Semantic proximity Read ↗

Mouse model of OPRM1 (A118G) polymorphism has altered hippocampal function.Semantic proximity Read ↗

Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.Semantic proximity Read ↗

Mouse model of the OPRM1 (A118G) polymorphism: differential heroin self-administration behavior compared with wild-type mice.Semantic proximity Read ↗

Increased ethanol drinking in "humanized" mice expressing the mu opioid receptor A118G polymorphism are mediated through sex-specific mechanisms.Semantic proximity Read ↗

Impact of OPRM1 (Mu-opioid Receptor Gene) A112G Polymorphism on Dual Oxycodone and Cocaine Self-administration Behavior in a Mouse Model.Semantic proximity Read ↗

A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability.Semantic proximity Read ↗

Mouse model of OPRM1 (A118G) polymorphism increases sociability and dominance and confers resilience to social defeat.Semantic proximity Read ↗

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