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Article

Mouse model of OPRM1 (A118G) polymorphism increases sociability and dominance and confers resilience to social defeat.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Feb 2015

Briand Lisa A, Hilario Monica, Dow Holly C, Brodkin Edward S, Blendy Julie A, Berton Olivier

Abstract excerpt

A single nucleotide polymorphism (SNP) in the human μ-opioid receptor gene (OPRM1 A118G) has been widely studied for its association in drug addiction, pain sensitivity, and, more recently, social behavior. The endogenous opioid system has been shown to regulate social distress and reward in a variety of animal models. However, mechanisms underlying the associations between the OPRM1 A118G SNP and these behaviors...

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Source

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Identifiers

PMID: 25716856
DOI: 10.1523/JNEUROSCI.4685-14.2015
PMCID: PMC4339361

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mouse model of OPRM1 (A118G) polymorphism increases sociability and dominance and confers resilience to social defeat.PMID 25716856Read ↗

Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior.Semantic proximity Read ↗

Oprm1 A112G, a single nucleotide polymorphism, alters expression of stress-responsive genes in multiple brain regions in male and female mice.Semantic proximity Read ↗

Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients.Semantic proximity Read ↗

Genetic variation in the behavioral effects of buprenorphine in female mice derived from a murine model of the OPRM1 A118G polymorphism.Semantic proximity Read ↗

Increased ethanol drinking in "humanized" mice expressing the mu opioid receptor A118G polymorphism are mediated through sex-specific mechanisms.Semantic proximity Read ↗

Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G.Semantic proximity Read ↗

Mouse model of the OPRM1 (A118G) polymorphism: differential heroin self-administration behavior compared with wild-type mice.Semantic proximity Read ↗

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