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Article

Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function.

Cell death & disease - 20 Jul 2018

Singh Bhupendra, Schoeb Trenton R, Bajpai Prachi, Slominski Andrzej, Singh Keshav K

Abstract excerpt

Mitochondrial DNA (mtDNA) depletion is involved in mtDNA depletion syndromes, mitochondrial diseases, aging and aging-associated chronic diseases, and other human pathologies. To evaluate the consequences of depletion of mtDNA in the whole animal, we created an inducible mtDNA-depleter mouse expressing, in the polymerase domain of POLG1, a dominant-negative mutation to induce depletion of mtDNA in various...

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Identifiers

PMID: 30026579
DOI: 10.1038/s41419-018-0765-9
PMCID: PMC6053453

Genes

MRPS5
TIMP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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