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Article

Mitochondrial DNA mutations attenuate Bleomycin-induced dermal fibrosis by inhibiting differentiation into myofibroblasts.

Matrix biology : journal of the International Society for Matrix Biology - 1 Sept 2024

Reiter Lena, Niehoff Nadine, Weiland Daniela, Helbig Doris, Eming Sabine A, Krieg Thomas, Etich Julia, Brachvogel Bent, Wiesner Rudolf J, Knuever Jana

Abstract excerpt

Post-mitotic, non-proliferative dermal fibroblasts have crucial functions in maintenance and restoration of tissue homeostasis. They are involved in essential processes such as wound healing, pigmentation and hair growth, but also tumor development and aging-associated diseases. These processes are energetically highly demanding and error prone when mitochondrial damage occurs. However, mitochondrial function in...

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PMID: 39009171
DOI: 10.1016/j.matbio.2024.07.002

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