Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue.

doi:10.1111/j.1474-9726.2010.00658.x

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Article

Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue.

Aging cell - 1 Apr 2011

Treiber Nicolai, Maity Pallab, Singh Karmveer, Kohn Matthias, Keist Alexander F, Ferchiu Florentina, Sante Lea, Frese Sebastian, Bloch Wilhelm, Kreppel Florian, Kochanek Stefan, Sindrilaru Anca, Iben Sebastian, Högel Josef, Ohnmacht Michael, Claes Lutz E, Ignatius Anita, Chung Jin H, Lee Min J, Kamenisch York, Berneburg Mark, Nikolaus Thorsten, Braunstein Kerstin, Sperfeld Anne-Dorte, Ludolph Albert C, Briviba Karlis, Wlaschek Meinhard, Florin Lore, Angel Peter, Scharffetter-Kochanek Karin

Abstract excerpt

The free radical theory of aging postulates that the production of mitochondrial reactive oxygen species is the major determinant of aging and lifespan. Its role in aging of the connective tissue has not yet been established, even though the incidence of aging-related disorders in connective tissue-rich organs is high, causing major disability in the elderly. We have now addressed this question experimentally by...

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PMID: 21108731
DOI: 10.1111/j.1474-9726.2010.00658.x

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