Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying

16 Jun 2025

Abstract excerpt

Hair pigmentation is regulated by melanocyte stem cells (MeSCs) within the hair follicle. Mitochondrial dysfunction is associated with hair depigmentation, primarily due to defects in melanogenesis. However, the mechanisms by which mitochondria support MeSCs during hair pigmentation remain obscure. In this study, we investigated the role of mitochondrial deoxyguanosine kinase (DGUOK), which provides guanosine and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hair Growth and Disorders
Share to melanin and skin pigmentation
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40522608
DOI: 10.1186/s13619-025-00242-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greyingPMID 40522608Read ↗

Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentialsSemantic proximity Read ↗

Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentationSemantic proximity Read ↗

BRN2 suppresses stress-induced hair greyingSemantic proximity Read ↗

The biology of human hair greyingSemantic proximity Read ↗

Aging, graying and loss of melanocyte stem cells.Semantic proximity Read ↗

[Melanocyte stem cells in adults].Semantic proximity Read ↗

Human Melanocyte Biology, Toxicology, and PathologySemantic proximity Read ↗

Mitochondrial Secrets of Youthfulness.Semantic proximity Read ↗

Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the NicheSemantic proximity Read ↗

Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine ApplicationsSemantic proximity Read ↗

Somatic mutations distinguish melanocyte subpopulations in human skinSemantic proximity Read ↗

Aging of the hair follicle pigmentation systemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.