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Article

Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors.

Cancer research - 1 Sept 2018

Lopez Sambrooks Cecilia, Baro Marta, Quijano Amanda, Narayan Azeet, Cui Wei, Greninger Patricia, Egan Regina, Patel Abhijit, Benes Cyril H, Saltzman W Mark, Contessa Joseph N

Abstract excerpt

Asparagine (N)-linked glycosylation is a posttranslational modification essential for the function of complex transmembrane proteins. However, targeting glycosylation for cancer therapy has not been feasible due to generalized effects on all glycoproteins. Here, we perform sensitivity screening of 94 lung cancer cell lines using NGI-1, a small-molecule inhibitor of the oligosaccharyltransferase (OST) that...

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Identifiers

PMID: 30026325
DOI: 10.1158/0008-5472.CAN-18-0505
PMCID: PMC6125176

Genes

EGFR
MET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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